Genomics

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MiR-200b is associated with cisplatin sensitivity in bladder cancer cells


ABSTRACT: We aimed to clarify the role of miR-200b in cisplatin (CDDP) sensitivity in bladder cancer (BCa). CDDP resistant T24 cells (T24RC) were transfected with a miR mimic negative control (NC) or a miR-200b mimic, after which cells were treated with or without CDDP. We found that ectopic miR-200b expression re-sensitized the T24RC cells to CDDP. Gene expression microarray analysis revealed that the combination of miR-200b and CDDP affected genes involved in CDDP sensitivity and cytotoxicity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE103250 | GEO | 2018/05/31

REPOSITORIES: GEO

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