Dataset Information


Global mRNA decay in Gluconobacter oxydans 621H

ABSTRACT: In this study we conducted genome-wide mRNA decay analysis to get further insights into the physiology of Gluconobacter oxydans. Overall design: The microarray analysis aimed at the determination of the mRNA level changes in G. oxydans after addition of rifampicin. The analysis was performed three times by independent biological replicates. G. oxydans cells were harvested for isolation of total RNA directly before (t0) and 2 min (t2), 5 min (t5), 10 min (t10) as well as 15 min (t15) after addition of rifampicin. Each sample after addition of rifampicin (tx) was compared to t0 samples.

INSTRUMENT(S): Agilent-064191 FZ_IBG1_4plex

ORGANISM(S): Gluconobacter oxydans 621H  

SUBMITTER: Tino Polen  

PROVIDER: GSE103428 | GEO | 2018-09-21


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Global mRNA decay and 23S rRNA fragmentation in Gluconobacter oxydans 621H.

Kranz Angela A   Steinmann Andrea A   Degner Ursula U   Mengus-Kaya Aliye A   Matamouros Susana S   Bott Michael M   Polen Tino T  

BMC genomics 20181016 1

<h4>Background</h4>Gluconobacter oxydans is a strictly aerobic Gram-negative acetic acid bacterium used industrially for oxidative biotransformations due to its exceptional type of catabolism. It incompletely oxidizes a wide variety of carbohydrates regio- and stereoselectively in the periplasm using membrane-bound dehydrogenases with accumulation of the products in the medium. As a consequence, only a small fraction of the carbon and energy source enters the cell, resulting in a low biomass yie  ...[more]

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