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Met induces mammary tumors with diverse histologies and is associated with poor outcome and human basal breast cancer

ABSTRACT: Elevated Met receptor tyrosine kinase (RTK) expression correlates with poor outcome in breast cancer, yet a causal role for Met in the development of breast cancer has not been directly established. To examine this question, we generated a transgenic mouse model that targets expression of an oncogenic Met receptor (MetMut) to the mammary epithelium. We show that MetMut induces mammary tumors with a variety of histopathologies that exhibit gene expression profiles sharing similarities with human basal and luminal breast tumor subtypes. Among all breast cancers, we further demonstrate that the Met receptor is primarily overexpressed in human basal and HER2 positive breast cancers, and that a Met associated gene expression signature identifies patients with poor prognosis. Keywords: Met, mammary, poor outcome, EMT, basal breast cancer Overall design: Common reference design. 26 samples (including 20 normal tissue and 32 tumor tissue samples) replicated twice as dye swaps, generating a total of 52 arrays.

INSTRUMENT(S): Agilent-012694 Whole Mouse Genome G4122A (Feature Number version)

ORGANISM(S): Mus Musculus

SUBMITTER: Robert Lesurf 

PROVIDER: GSE10450 | GEO | 2009-03-30



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