Transcriptomics,Genomics

Dataset Information

48

No reliable gene expression biomarkers of current or impending neurocognitive impairment in peripheral blood monocytes of persons living with HIV


ABSTRACT: Analysis of HIV-associated neurocognitive disorder (HAND) in peripheral monocytes at the gene expression level. The hypothesis tested in the present study was that monocyte gene expression would be predictive of HAND. Results provide information of the associations between monocytes and global neurocognitive function. Overall design: Total RNA obtained from monocytes purified from the blood of HIV+ and HIV- subjects with neurocognitive profiling.

INSTRUMENT(S): Illumina HumanHT-12 V4.0 expression beadchip

SUBMITTER: Steve Horvath 

PROVIDER: GSE104640 | GEO | 2017-10-07

SECONDARY ACCESSION(S): PRJNA413532

REPOSITORIES: GEO

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Publications

No reliable gene expression biomarkers of current or impending neurocognitive impairment in peripheral blood monocytes of persons living with HIV.

Quach Austin A   Horvath Steve S   Nemanim Natasha N   Vatakis Dimitrios D   Witt Mallory D MD   Miller Eric N EN   Detels Roger R   Langfelder Peter P   Shapshak Paul P   Singer Elyse J EJ   Levine Andrew J AJ  

Journal of neurovirology 20180326 3


Events leading to and propagating neurocognitive impairment (NCI) in HIV-1-infected (HIV+) persons are largely mediated by peripheral blood monocytes. We previously identified expression levels of individual genes and gene networks in peripheral blood monocytes that correlated with neurocognitive functioning in HIV+ adults. Here, we expand upon those findings by examining if gene expression data at baseline is predictive of change in neurocognitive functioning 2 years later. We also attempt to v  ...[more]

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