Transcriptomics,Genomics

Dataset Information

51

Transcriptome analysis of HIV-infected peripheral blood monocytes


ABSTRACT: Immunologic dysfunction, mediated via monocyte activity, has been implicated in the development of HIV-associated neurocognitive disorder (HAND). We hypothesized that transcriptome changes in peripheral blood monocytes relate to neurocognitive functioning in HIV+ individuals, and that such alterations could be useful as biomarkers of worsening HAND. METHODS: mRNA was isolated from the monocytes of 86 HIV+ adults and analyzed with the Illumina HT-12 v4 Expression BeadChip. Neurocognitive functioning, HAND diagnosis, and other clinical and virologic variables were determined. Overall design: mRNA was isolated from the monocytes of 86 HIV+ adults and analyzed with the Illumina HT-12 v4 Expression BeadChip. Neurocognitive functioning, HAND diagnosis, and other clinical and virologic variables were determined.

INSTRUMENT(S): Illumina HumanHT-12 V4.0 expression beadchip

SUBMITTER: Steve Horvath  

PROVIDER: GSE50011 | GEO | 2015-04-02

SECONDARY ACCESSION(S): PRJNA215806

REPOSITORIES: GEO

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Publications

Transcriptome analysis of HIV-infected peripheral blood monocytes: gene transcripts and networks associated with neurocognitive functioning.

Levine Andrew J AJ   Horvath Steve S   Miller Eric N EN   Singer Elyse J EJ   Shapshak Paul P   Baldwin Gayle C GC   Martínez-Maza Otoniel O   Witt Mallory D MD   Langfelder Peter P  

Journal of neuroimmunology 20130926 1-2


Immunologic dysfunction, mediated via monocyte activity, has been implicated in the development of HIV-associated neurocognitive disorder (HAND). We hypothesized that transcriptome changes in peripheral blood monocytes relate to neurocognitive functioning in HIV+ individuals, and that such alterations could be useful as biomarkers of worsening HAND.mRNA was isolated from the monocytes of 86 HIV+ adults and analyzed with the Illumina HT-12 v4 Expression BeadChip. Neurocognitive functioning, HAND  ...[more]

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