MicroRNA-130a and miR-212 disrupt the intestinal epithelial barrier through modulation of peroxisome proliferator-activated receptor gamma and occludin expression in chronic SIV-infected rhesus macaques

ABSTRACT: We profiled and characterized mRNA expression exclusively in colonic epithelium (CE) of 4 chronically SIV-infected and 4 control rhesus macaques (RMs). Further analysis identified significant dowregulation of genes Genes associated with ion transport, epithelial barrier integrity/function, protection against oxidative injury, double stranded DNA damage repair and autophagy. Similarly, mRNA expression of genes associated with interferon response, anti-microbial defense, apoptosis, oxidative DNA damage, endoplasmic reticulum stress and inflammasome signaling were markedly upregulated.

ORGANISM(S): Macaca mulatta

PROVIDER: GSE104771 | GEO | 2018/02/01

REPOSITORIES: GEO