Ontology highlight
ABSTRACT:
INSTRUMENT(S): [MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version]
SUBMITTER: Yoonkyung Won
PROVIDER: GSE104795 | GEO | 2017-10-10
SECONDARY ACCESSION(S): PRJNA413833
REPOSITORIES: GEO
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Won Yoonkyung Y Shin Youngnim Y Chun Churl-Hong CH Cho Yongsik Y Ha Chul-Won CW Kim Jin-Hong JH Chun Jang-Soo JS
Annals of the rheumatic diseases 20160222 11
<h4>Objective</h4>The zinc-ZIP8-MTF1 axis induces metallothionein (MT) expression and is a catabolic regulator of experimental osteoarthritis (OA) in mice. The main aim of the current study was to explore the roles and underlying molecular mechanisms of MTs in OA pathogenesis.<h4>Methods</h4>Experimental OA in mice was induced by destabilisation of the medial meniscus or intra-articular injection of adenovirus carrying a target gene (Ad-Zip8, Ad-Mtf1, Ad-Epas1, Ad-Nampt, Ad-Mt1 or Ad-Mt2) into w ...[more]