Transcriptomics,Genomics

Dataset Information

161

RNAseq Analysis of Mouse Stomach and Intestines Following Vertical Sleeve Gastrectomy


ABSTRACT: Bariatric surgery, an effective treatment for obesity and diabetes, leads to profound remodeling of whole body energy homeostasis. We utilized a mouse model of vertical sleeve gastrectomy (VSG), a common bariatric surgery as a tool to identify novel secreted proteins and peptides that might act as important metabolic regulators. We analyzed gene expression in the stomach and intestines following VSG or sham surgery in diet-induced obese mice and sought to identify differentially regulated genes encoding secreted proteins/peptides. Overall design: Gene expression analysis of 5 different mouse intestinal tissues after VSG or sham surgery

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Daniel David Kaplan 

PROVIDER: GSE104956 | GEO | 2017-10-14

SECONDARY ACCESSION(S): PRJNA414231

REPOSITORIES: GEO

altmetric image

Publications


Ghrelin, an appetite-stimulatory hormone secreted by the stomach, was discovered as a ligand for the growth hormone secretagogue receptor (GHSR). Through GHSR, ghrelin stimulates growth hormone (GH) secretion, a function that evolved to protect against starvation-induced hypoglycemia. Though the biology mediated by ghrelin has been described in great detail, regulation of ghrelin action is poorly understood. Here, we report the discovery of liver-expressed antimicrobial peptide 2 (LEAP2) as an e  ...[more]

Similar Datasets

2014-03-27 | E-GEOD-53782 | ArrayExpress
| GSE121489 | GEO
| GSE94842 | GEO
| GSE106883 | GEO
2019-02-09 | PXD011455 | Pride
| GSE121486 | GEO
2017-06-19 | ST000729 | MetabolomicsWorkbench
2017-06-19 | ST000728 | MetabolomicsWorkbench
| GSE121490 | GEO
| PRJNA414231 | ENA