Dataset Information


The human circulating miRNome reflects multiple diseases associated with short-term exposure to traffic-related air pollution

ABSTRACT: The study comprises of 24 subjects that have been exposed to low (H) and high dose (O) ambient traffic pollution. Each subject has been exposed to 2 different exposure site. Blood samples were taken at both sites of which circulating miRNAs in plasma have been prepared Overall design: 48 Samples total

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Julian Krauskopf  

PROVIDER: GSE106221 | GEO | 2018-02-06


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The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution.

Krauskopf Julian J   Caiment Florian F   van Veldhoven Karin K   Chadeau-Hyam Marc M   Sinharay Rudy R   Chung Kian Fan KF   Cullinan Paul P   Collins Peter P   Barratt Benjamin B   Kelly Frank J FJ   Vermeulen Roel R   Vineis Paolo P   de Kok Theo M TM   Kleinjans Jos C JC  

Environment international 20180128

Traffic-related air pollution is a complex mixture of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide (NO2). PM exposure contributes to the pathogenesis of many diseases including several types of cancer, as well as pulmonary, cardiovascular and neurodegenerative diseases. Also exposure to NO2 has been related to increased cardiovascular mortality. In search of an early diagnostic biomarker for improved air pollution-associated health risk assessment, recent human studie  ...[more]

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