The genomic landscape of the fungal specific SWI/SNF complex subunit, Snf6, in Candida albicans

ABSTRACT: We have focused our investigation on the characterization of the role of the fungal specific SWI/SNF subunit, Snf6. Our data show that, although the C. albicans subunit has only limited sequence similarity to other fungal orthologs, Snf6 was copurified with SWI/SNF complex subunits including the catalytic ATPase subunit, Snf2. We show that Snf6 plays a critical role in biological processes that are essential for fungal pathogenesis including carbon metabolic flexibility, stress response and morphogenesis. The Snf6 regulon was determined by combining both genome-wide location (ChIP-chip) and transcriptional profiling (microarrays) to identify targets of the SWI/SNF complex under both yeast- and hyphal-promoting conditions.

ORGANISM(S): Candida albicans

PROVIDER: GSE106278 | GEO | 2017/10/28

SECONDARY ACCESSION(S): PRJNA416123

REPOSITORIES: GEO