Dataset Information


Chromatin remodeler CHD8 in CNS myelination and remyelination

ABSTRACT: Mutations in CHD8, an ATP-dependent chromodomain-helicase-DNA-binding protein 8, are known to cause a set of Autism Spectrum Disorders (ASD). We found that CHD8 is highly expressed in myelinating oligodendrocytes (OL) and their progenitors in the developing central nervous system (CNS). We performed CHD8 chIP-seq analysis in cultured oligodendrocytes. Overall design: 11 samples: RNA-seq:2 Control Samples vs 2 cKO samples; ChIP-seq: 2 Chd8samples, 1 chd7 sample; H3K4me3 ChIP-seq: 1 control vs 1 Ch8cko; ATAC-seq 1 control vs 1 Chd8cKO

INSTRUMENT(S): Illumina HiSeq 2000 (Rattus norvegicus)

SUBMITTER: Richard Lu 

PROVIDER: GSE107919 | GEO | 2018-06-20


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Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.

Zhao Chuntao C   Dong Chen C   Frah Magali M   Deng Yaqi Y   Marie Corentine C   Zhang Feng F   Xu Lingli L   Ma Zhixing Z   Dong Xinran X   Lin Yifeng Y   Koenig Scott S   Nait-Oumesmar Brahim B   Martin Donna M DM   Wu Laiman N LN   Xin Mei M   Zhou Wenhao W   Parras Carlos C   Lu Q Richard QR  

Developmental cell 20180601 6

Disruptive mutations in chromatin remodeler CHD8 cause autism spectrum disorders, exhibiting widespread white matter abnormalities; however, the underlying mechanisms remain elusive. We show that cell-type specific Chd8 deletion in oligodendrocyte progenitors, but not in neurons, results in myelination defects, revealing a cell-intrinsic dependence on CHD8 for oligodendrocyte lineage development, myelination and post-injury remyelination. CHD8 activates expression of BRG1-associated SWI/SNF comp  ...[more]

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