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Chromatin remodeler CHD8 in CNS myelination and remyelination

ABSTRACT: Mutations in CHD8, an ATP-dependent chromodomain-helicase-DNA-binding protein 8, are known to cause a set of Autism Spectrum Disorders (ASD). We found that CHD8 is highly expressed in myelinating oligodendrocytes (OL) and their progenitors in the developing central nervous system (CNS). We performed CHD8 chIP-seq analysis in cultured oligodendrocytes.

ORGANISM(S): Mus musculus Rattus norvegicus

PROVIDER: GSE107919 | GEO | 2018/06/20

REPOSITORIES: GEO

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Chromatin remodeler CHD8 in CNS myelination and remyelination

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CHD8 Suppression Impacts on Histone H3 Lysine 36 Trimethylation and Alters RNA Alternative Splicing

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