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Characterization of distinct states of human naïve and primed pluriopotency

ABSTRACT: Pluripotency of mammalian stem cells is stabilized at different status depending upon the extracellular stimuli of their environment. Now, there is a consensus that mouse embryonic stem cells (mESCs) and iPSCs (miPSCs) represent undifferentiated status very close to ground-state of mammalian development when cultured in optimal condition. Since they have not been activated to commit into any lineages, they are stated as “naïve-state stem cells”. In contrast, human ESCs (hESCs), hiPSCs, and mEpiSCs are considered to possess partially differentiated characteristics compared with mESCs and miPSCs. Thus, they are stated as “primed-state stem cells”. Investigation of the prerequisites for establishment of the naïve-state is significantly important to fully understand mammalian development and to extrapolate the technologies developed with mouse ES/iPS cells for human. We used expression data to understand the gene expression profile and identified distinct characteristics on pluripotent state.

ORGANISM(S): Homo sapiens

PROVIDER: GSE107969 | GEO | 2017/12/13

SECONDARY ACCESSION(S): PRJNA422057

REPOSITORIES: GEO

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Characterization of distinct states of mouse naïve and primed pluriopotency

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