Transcriptomics

Dataset Information

151

Genome-wide maps of EWS-FLI1 binding sites and histone modification in murine Ewing sarcoma cells


ABSTRACT: We identified global DNA binding properties of EWS-FLI1 in mouse Ewing sarcoma. GGAA microsatellites were found as binding sites of EWS-FLI1 but with less frequency than that in human Ewing sarcoma, and genomic distribution is not conserved between human and mouse. Overall design: Examination of binding sites of EWS-FLI1, histone H3K27Ac and H3K27me3 in two Ewing sarcoma cell lines.

INSTRUMENT(S): Illumina Genome Analyzer (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Takuro Nakamura  

PROVIDER: GSE108631 | GEO | 2018-07-25

REPOSITORIES: GEO

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Publications

EWS-FLI1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma.

Shimizu Rikuka R   Tanaka Miwa M   Tsutsumi Shuichi S   Aburatani Hiroyuki H   Yamazaki Yukari Y   Homme Mizuki M   Kitagawa Yoshimasa Y   Nakamura Takuro T  

Cancer science 20180718 9


EWS-FLI1 constitutes an oncogenic transcription factor that plays key roles in Ewing sarcoma development and maintenance. We have recently succeeded in generating an ex vivo mouse model for Ewing sarcoma by introducing EWS-FLI1 into embryonic osteochondrogenic progenitors. The model well recapitulates the biological characteristics, small round cell morphology, and gene expression profiles of human Ewing sarcoma. Here, we clarified the global DNA binding properties of EWS-FLI1 in mouse Ewing sar  ...[more]

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