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Long non-coding RNAs have age-dependent diurnal expression that correlates with age-related changes in genome-wide facultative heterochromatin


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2500 (Danio rerio)

SUBMITTER: William J. Belden  

PROVIDER: GSE109856 | GEO | 2018-01-30

SECONDARY ACCESSION(S): GSE109854 GSE109855S-EPMC6206985

REPOSITORIES: GEO

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Long non-coding RNAs have age-dependent diurnal expression that coincides with age-related changes in genome-wide facultative heterochromatin.

Park Jinhee J   Belden William J WJ  

BMC genomics 20181029 1


<h4>Background</h4>Disrupted diurnal rhythms cause accelerated aging and an increased incidence in age-related disease and morbidity. The circadian clock governs cell physiology and metabolism by controlling transcription and chromatin. The goal of this study is to further understand the mechanism of age-related changes to circadian chromatin with a focus on facultative heterochromatin and diurnal non-coding RNAs.<h4>Results</h4>We performed a combined RNA-seq and ChIP-seq at two diurnal time-po  ...[more]

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