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RNA seq from liver samples of C57BL/6 mice to study the gene expression synchrony of Plasmodium stages with host circadian cycle.

ABSTRACT: The Plasmodium life cycle parasites differentiate and proliferate synchronously, paralleling the vertebrate host's circadian rhythm. Here we report that expression of carbohydrate metabolism and inflammatory genes in IFNγ-primed leukocytes and liver cells from infected mice are boosted in P. chabaudi-infected mice. In addition, a rhythmic gene expression of PPARG and TNFα, which are key regulators of glucose metabolism, parallel blood glucose levels across the circadian cycle in infected mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE109908 | GEO | 2018/06/01

REPOSITORIES: GEO

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