Genomics

Dataset Information

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RNA-seq analysis of gene expression patterns of cells from stem-cell-derived-synthetic-embryos, named as 'ETX-embryos'.


ABSTRACT: We analyze the difference between ETX-side1 cells and ETX-side2 cells. Side1 cells are associated with the anterior domain of the natural embryo, side2 cells are associated with the posterior domain of natural embryo. Overall design: Examination of gene expression patterns of cells selected from different domains of 3 individual ETX-embryo (individuals labelled as A, B, C).

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Ran Wang  

PROVIDER: GSE110105 | GEO | 2019-02-01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE110105_Genes.FPKM.Norm.txt.gz Txt
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Publications

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures.

Sozen Berna B   Amadei Gianluca G   Cox Andy A   Wang Ran R   Na Ellen E   Czukiewska Sylwia S   Chappell Lia L   Chappell Lia L   Voet Thierry T   Michel Geert G   Jing Naihe N   Glover David M DM   Zernicka-Goetz Magdalena M  

Nature cell biology 20180723 8


Embryonic stem cells can be incorporated into the developing embryo and its germ line, but, when cultured alone, their ability to generate embryonic structures is restricted. They can interact with trophoblast stem cells to generate structures that break symmetry and specify mesoderm, but their development is limited as the epithelial-mesenchymal transition of gastrulation cannot occur. Here, we describe a system that allows assembly of mouse embryonic, trophoblast and extra-embryonic endoderm s  ...[more]

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