Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Beta cell dysfunction and identity loss induced by low dose of Interleukin-1β is associated with changes in histone acetylation and gene expression [RNA-seq]

ABSTRACT: We report maturity loss and dysfunction of primary mouse islets exposed to prolonged low Interleukin-1B exposure is associated with a decreassed expresion of key beta cell genes and a decreased H3K27ac mark

ORGANISM(S): Mus musculus

PROVIDER: GSE110690 | GEO | 2019/08/05

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Beta cell dysfunction and identity loss induced by low dose of Interleukin-1β is associated with changes in histone acetylation and gene expression [ChIP-seq]

Project description:We report maturity loss and dysfunction of primary mouse islets exposed to prolonged low Interleukin-1B exposure is associated with a decreassed expresion of key beta cell genes and a decreased H3K27ac mark

2019-08-05 | GSE110689 | GEO

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β [16S]

Project description:Acute gastrointestinal infection with intracellular pathogens like Salmonella Typhimurium triggers the release of the proinflammatory cytokine interleukin 1β (IL-1β). However, the role of IL-1β in intestinal defense against Salmonella remains unclear. Here, we show that IL-1b production is detrimental during Salmonella infection. Mice lacking IL-1b (IL-1b -/-) failed to recruit neutrophils to the gut during infection, which reduced tissue damage and prevented depletion of short-chain fatty acid-producing commensals. Changes in epithelial cell metabolism that typically support pathogen expansion, such as switching energy production from fatty acid oxidation to fermentation, were absent in infected IL-1b -/- mice which inhibited Salmonella expansion. Additionally, we found that IL-1b induces expression of complement anaphylatoxins and suppresses the complement-inactivator Carboxypeptidase N (CPN1). Disrupting this process via IL-1b loss prevented mortality in Salmonella-infected IL-1b -/- mice. Finally, we found that IL-1b expression correlates with expression of the complement receptor in patients suffering from sepsis, but not uninfected patients and healthy individuals. Thus, Salmonella exploits IL-1b signaling to outcompete commensal microbes and establish gut colonization. Moreover, our findings identify the intersection of IL-1b signaling and the complement system as key host factors involved in controlling mortality during invasive Salmonellosis.

2024-01-08 | GSE252070 | GEO

Salmonella manipulates the host to drive pathogenicity via induction of interleukin 1β [RNA-Seq]

2024-01-08 | GSE252069 | GEO

Interleukin-1β and Cancer.

Project description: Not available

| S-EPMC7408158 | biostudies-literature

Beta cell dysfunction and identity loss induced by low dose of Interleukin-1β is associated with changes in histone acetylation and gene expression [ChIP-seq]

Project description:Beta cell dysfunction and identity loss induced by low dose of Interleukin-1β is associated with changes in histone acetylation and gene expression [ChIP-seq]

| PRJNA434283 | ENA

Beta cell dysfunction and identity loss induced by low dose of Interleukin-1β is associated with changes in histone acetylation and gene expression [RNA-seq]

Project description:Beta cell dysfunction and identity loss induced by low dose of Interleukin-1β is associated with changes in histone acetylation and gene expression [RNA-seq]

| PRJNA434284 | ENA

Liver Sinusoidal Endothelial Cells Promote Metabolic Dysfunction-associated Steatohepatitis Progression via Interleukin-1R1-mediated Chemokine Production Induced by Macrophage-derived Interleukin-1β.

Project description: Not available

| S-EPMC12865640 | biostudies-literature

Proteomics analysis of human islets treated with IL-1b and IFN-g

Project description:Human islets were treated with IL-1b and IFN-g for 24h, digested with trypsin, multiplexed with TMT-10, fractionated by high pH reverse-phase chromatography and analyzed by tandem LC-MS/MS.

2019-10-25 | PXD009131 | Pride

Omentin-1 alleviate interleukin-1β(IL-1β)-induced nucleus pulposus cells senescence.

Project description: Not available

| S-EPMC9275897 | biostudies-literature

scRNA-seq of pancreatic islets from adult male mice with Fltp-reporter sorting and pancreatic head-tail separation

Project description:Single-cell RNA sequencing of pancreatic islets from adult male mice. To disect islet heterogeneity we sorted cells based on anatomical location and maturity marker (Fltp).

2022-12-23 | GSE211796 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data