Transcriptomics,Genomics

Dataset Information

155

Profiling of differential RNAs in LY500307-treated B16 cells and control-treated B16 cells


ABSTRACT: In this study, we examined the differential RNA profile of LY500307-treated B16 cells compared with control-treated B16 cells Overall design: We used RNA sequencing to compare the differential RNAs of LY500307-treated B16 cells compared with control-treated B16 cells

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Shengtao Zhou  

PROVIDER: GSE110769 | GEO | 2018-04-25

REPOSITORIES: GEO

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Publications

Pharmacological activation of estrogen receptor beta augments innate immunity to suppress cancer metastasis.

Zhao Linjie L   Huang Shuang S   Mei Shenglin S   Yang Zhengnan Z   Xu Lian L   Zhou Nianxin N   Yang Qilian Q   Shen Qiuhong Q   Wang Wei W   Le Xiaobing X   Lau Wayne Bond WB   Lau Bonnie B   Wang Xin X   Yi Tao T   Zhao Xia X   Wei Yuquan Y   Warner Margaret M   Gustafsson Jan-Åke JÅ   Zhou Shengtao S  

Proceedings of the National Academy of Sciences of the United States of America 20180328 16


Metastases constitute the greatest causes of deaths from cancer. However, no effective therapeutic options currently exist for cancer patients with metastasis. Estrogen receptor β (ERβ), as a member of the nuclear receptor superfamily, shows potent tumor-suppressive activities in many cancers. To investigate whether modulation of ERβ could serve as a therapeutic strategy for cancer metastasis, we examined whether the selective ERβ agonist LY500307 could suppress lung metastasis of triple-negativ  ...[more]

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