Dataset Information

Proteomics of B16-F10 cells treated by carboxylic acids

ABSTRACT: To elucidate the mechanisms by which the four carboxylic acids—3-phenyllactic acid, lactic acid, L-pyroglutamic acid, and malic acid—inhibit melanin production in B16-F10 cells, a comparative proteomic analysis was conducted to assess changes in protein expression.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Melanocyte

DISEASE(S): Skin Melanoma

SUBMITTER: Yu-Pei Chen

LAB HEAD: Yu-Pei Chen

PROVIDER: PXD061919 | Pride | 2025-05-07

REPOSITORIES: Pride

ACCESS DATA

Dataset's files

Source:

			Action	DRS
	20250213_103302_YAS202501150047-1.sne	Other
	YAS202501150047-1-CON-1_S6-B11_1_14692.d.zip	Other
	YAS202501150047-1-CON-2_S6-B12_1_14693.d.zip	Other
	YAS202501150047-1-CON-3_S6-C1_1_14694.d.zip	Other
	YAS202501150047-1-L-P-1_S6-B2_1_14681.d.zip	Other

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Publications

Inhibition of Tyrosinase and Melanogenesis by Carboxylic Acids: Mechanistic Insights and Safety Evaluation.

Chen Yu-Pei YP Li Mingyu M Liu Zirong Z Wu Jinxiong J Chen Fangfang F Zhang Shudi S

Molecules (Basel, Switzerland) 20250407 7

It is well established that certain carboxylic acid compounds can effectively inhibit tyrosinase activity. This study investigated the mechanisms by which four carboxylic acid compounds-3-phenyllactic acid, lactic acid, L-pyroglutamic acid, and malic acid-inhibit tyrosinase and melanogenesis. IC<sub>50</sub> values for mushroom tyrosinase inhibition ranged from 3.38 to 5.42 mM, with 3-phenyllactic acid (3.50 mM), lactic acid (5.42 mM), and malic acid (3.91 mM) exhibiting mixed-type inhibition, w ...[more]

PMID: 40286213

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