Transcriptomics,Genomics

Dataset Information

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Gene Expression Analysis of metastatic CRPC cell line C4-2B treated with the dual BET-kinase inhibitor MA4-022-1


ABSTRACT: We identified BRD4 as an epigenetic regulator of the prostate lineage specific gene HOXB13 during progression of the disease from an androgen dependent to an androgen independent state. Overall design: The design was to identify novel genes that are essential for CRPC growth and treaan be targeted with MA4--022-1

INSTRUMENT(S): Illumina HiSeq 1500 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Kiran Mahajan  

PROVIDER: GSE112298 | GEO | 2019-03-01

REPOSITORIES: GEO

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Publications


Resistance to androgen receptor (AR) antagonists is a significant problem in the treatment of castration-resistant prostate cancers (CRPC). Identification of the mechanisms by which CRPCs evade androgen deprivation therapies (ADT) is critical to develop novel therapeutics. We uncovered that CRPCs rely on BRD4-HOXB13 epigenetic reprogramming for androgen-independent cell proliferation. Mechanistically, BRD4, a member of the BET bromodomain family, epigenetically promotes HOXB13 expression. Consis  ...[more]