Dataset Information


Whole blood transcriptome analysis in amyotrophic lateral sclerosis: a biomarker study [HT12_V4]

ABSTRACT: Transcriptome-wide analysis of whole blood gene expression profiles of ALS patients, gender- and age-matched controls and patients diagnosed with diseases mimicking ALS at a tertiary referral center for motor neuron diseases. Overall design: mRNA was obtained from whole blood around the time of diagnosis and expression profiles were compared between ALS patients, controls and mimics in a biomarker design.

INSTRUMENT(S): Illumina HumanHT-12 V4.0 expression beadchip

SUBMITTER: Jan Herman Veldink 

PROVIDER: GSE112680 | GEO | 2018-04-05


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GSE112680_HT12_V4_preQC_nonnormalized.txt.gz Txt
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The biological pathways involved in amyotrophic lateral sclerosis (ALS) remain elusive and diagnostic decision-making can be challenging. Gene expression studies are valuable in overcoming such challenges since they can shed light on differentially regulated pathways and may ultimately identify valuable biomarkers. This two-stage transcriptome-wide study, including 397 ALS patients and 645 control subjects, identified 2,943 differentially expressed transcripts predominantly involved in RNA bindi  ...[more]

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