Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Brain
DISEASE(S): Amyotrophic Lateral Sclerosis
SUBMITTER: Enrique SantamarÃa
LAB HEAD: Enrique Santamaria
PROVIDER: PXD021630 | Pride | 2021-09-09
REPOSITORIES: Pride
Lachén-Montes Mercedes M Mendizuri Naroa N Ausin Karina K Andrés-Benito Pol P Ferrer Isidro I Fernández-Irigoyen Joaquín J Santamaría Enrique E
International journal of molecular sciences 20201105 21
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis during disease progression. Despite smell impairment being considered a potential non-motor finding in ALS, the pathobiochemistry at the olfactory level remains unknown. Here, we applied an olfactory quantitative proteotyping approach to analyze the magnitude of the olfactory bu ...[more]