Proteomics

Dataset Information

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Olfactory bulb proteomics in human Alzheimer's disease


ABSTRACT: Olfactory dysfunction is among the earliest features of Alzheimer´s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- proteome analysis was performed across different AD stages using a label-free approach.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo sapiens  

TISSUE(S): Brain

DISEASE(S): Not Available

SUBMITTER: Enrique Santamaría  

LAB HEAD: ENRIQUE SANTAMARIA

PROVIDER: PXD005319 | Pride | 2018-01-16

REPOSITORIES: pride

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Publications

Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression.

Lachén-Montes Mercedes M   González-Morales Andrea A   Zelaya María Victoria MV   Pérez-Valderrama Estela E   Ausín Karina K   Ferrer Isidro I   Fernández-Irigoyen Joaquín J   Santamaría Enrique E  

Scientific reports 20170822 1


Olfactory dysfunction is among the earliest features of Alzheimer's disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- proteome analysis showed a stage-dependent synaptic proteostasis impairment during AD evolution. In addition to progressive modulation of tau and amyloid precursor protein (APP) interactomes, network-driven proteomics revealed an early disruption of upstream and downstream p38  ...[more]

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