Genomics

Dataset Information

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Bivalent chromatin domains in glioblastoma multiforme reveal an epigenetic signature of early neural development mediated by SHH and Wnt signaling


ABSTRACT: We performed ChIP-seq for H3K27me3 and H3K4me3 to identify bivalent chromatin regions in T98G Glioblastoma multiforme cells. Overall design: ChIP-seq for H3K4me3, H3K27me3 and Input in T98G cells.

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

SUBMITTER: Vishy Iyer  

PROVIDER: GSE113361 | GEO | 2018-04-19

REPOSITORIES: GEO

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Publications

Bivalent Chromatin Domains in Glioblastoma Reveal a Subtype-Specific Signature of Glioma Stem Cells.

Hall Amelia Weber AW   Battenhouse Anna M AM   Shivram Haridha H   Morris Adam R AR   Cowperthwaite Matthew C MC   Shpak Max M   Iyer Vishwanath R VR  

Cancer research 20180316 10


Glioblastoma multiforme (GBM) can be clustered by gene expression into four main subtypes associated with prognosis and survival, but enhancers and other gene-regulatory elements have not yet been identified in primary tumors. Here, we profiled six histone modifications and CTCF binding as well as gene expression in primary gliomas and identified chromatin states that define distinct regulatory elements across the tumor genome. Enhancers in mesenchymal and classical tumor subtypes drove gene exp  ...[more]

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