Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)
ORGANISM(S): Homo sapiens
SUBMITTER: liming chen
PROVIDER: GSE114213 | GEO | 2018-12-26
REPOSITORIES: GEO
Action | DRS | |||
---|---|---|---|---|
GSE114213_T47D-TRPS1_peaks.bed.gz | Bed | |||
GSE114213_T47D_control-CHD4_htcount.txt.gz | Txt | |||
GSE114213_T47D_control-TRPS1_htcount.txt.gz | Txt | |||
GSE114213_extractSeq.py.gz | Other |
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Wang Yuzhi Y Lin Xue X Gong Xue X Wu Lele L Zhang Jun J Liu Weiguang W Li Jian J Chen Liming L
Oncogenesis 20181219 12
Transcriptional repressor GATA binding 1 (TRPS1), an atypical GATA transcription factor, functions as a transcriptional repressor and is also implicated in human cancers. However, the underlying mechanism of TRPS1 contributing to malignancy remains obscure. In the current study, we report that TRPS1 recognizes both gene proximal and distal transcription start site (TSS) sequences to repress gene expression. Co-IP mass spectrometry and biochemical studies showed that TRPS1 binds to CHD4/NuRD(MTA2 ...[more]