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Distinct transcriptional profiles of anti-viral CD4+ T cells based on CD25 surface expression

ABSTRACT: Trascriptional analysis of CD2 hi and CD25 lo CD4+ effector T cells during acute viral infection. SMARTA cells were transferred into B6 mice, followed by infection with LCMV. At day 5 post-infection, CD25 hi and CD25 lo SMARTA cells were isolated from the spleen by FACS. Consistent with our prior studies showing that CD25 lo early effector cells give rise to both Tfh effector cells and memory T cells, we observed gene expression in the CD25 lo population consistent with Tfh differentiation. Conversely, CD25 hi effector cells expressed markers consistent with Th1 differentiation and short-term survival.

ORGANISM(S): Mus musculus

PROVIDER: GSE114884 | GEO | 2018/05/25

REPOSITORIES: GEO

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Generation and purification of Th1 and Th2 effector and memory CD4+ T cells

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