Transcriptomics

Dataset Information

21

Gene expression changes during primate postnatal brain development


ABSTRACT: In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. During human evolution sexual maturation has been delayed relative to other primates and this may have played a critical role for both the increase of human brain size and the rise of human-specific cognitive traits . We measured the timing of gene expression changes in the brains of humans, chimpanzees, and rhesus macaques throughout postnatal development. Overall design: Human, chimpanzee and rhesus macaque post-mortem brain samples from the dorsolateral prefrontal cortex region were collected. The caudate nucleus region was additionally sampled for humans. The age ranges of the individuals in all three species covered the respective species' postnatal maturation period from infancy to young adulthood. RNA extracted from the dissected tissue was hybridized to Affymetrix® U133-plus2.0 GeneChip® arrays.

INSTRUMENT(S): Affymetrix GeneChip Human Genome U133 Plus 2.0 Array [HGU133Plus2_Hs_ENSG (v11.0.1) CDF]

SUBMITTER: Mehmet Somel   

PROVIDER: GSE11512 | GEO | 2009-03-10

SECONDARY ACCESSION(S): PRJNA106343

REPOSITORIES: GEO

altmetric image

Publications

Sorry, this publication's infomation has not been loaded in the Indexer, please go directly to PUBMED or Altmetric.

Similar Datasets

2011-06-10 | E-GEOD-11512 | ArrayExpress
2009-03-10 | GSE15163 | GEO
2012-03-27 | E-GEOD-15163 | ArrayExpress
2009-03-10 | GSE11528 | GEO
2011-06-10 | E-GEOD-11528 | ArrayExpress
2016-01-16 | E-GEOD-67978 | ArrayExpress
2011-12-09 | GSE29356 | GEO
| GSE22521 | GEO
2012-06-26 | E-GEOD-29138 | ArrayExpress
2011-12-17 | E-GEOD-29356 | ArrayExpress