Genome-wide fork-collapse sites in MEFs from ATR inhibition [mouse]

ABSTRACT: Transient obstruction of DNA polymerase progression activates the ATR checkpoint kinase, which suppresses fork breakage, strand resection, and RPA accumulation. Herein, we use a developed DNA break-detection assay, BrITL, to identify replication-problematic loci (RPLs) that become processed into persistent double-strand breaks across the mammalian genome from ATR inhibition.

ORGANISM(S): Mus musculus

PROVIDER: GSE115624 | GEO | 2018/10/04

REPOSITORIES: GEO