Cohesin occupancy and composition at enhancers and promoters are linked to DNA replication origin proximity in Drosophila

ABSTRACT: Cohesin subunits, the Nipped-B cohesin loader, the MED1 and MED30 subunits of the Mediator complex, and the Fs(1)h BET domain protein were mapped by ChIP-seq in ML-DmBG3-c2 cells and their effects on each other's association with promoters, enhancers, Polycomb Response Elements, and DNA replication origins were measured. DNA replication in early S phase was measured by ChIP-seq and correlated with functional element occupancy by cohesin.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE118484 | GEO | 2019/02/20

REPOSITORIES: GEO