Genomics

Dataset Information

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Expression data from mouse optic nerve and optic tract


ABSTRACT: A membrane protein SIRPα (CD172a) interacts with another membrane protein CD47 and thereby constitutes a cell–cell contact signal. To investigate the functional role of CD47-SIRPα signal in the brain, we analyzed the effect of genetic ablation of CD47-SIRPα signal on the gene expression profile in specific brain regions by the use of microarrays. Overall design: Total RNAs were prepared from the white matter (optic nerve and optic tract) of wild-type or CD47 knockout mice. Total RNAs from five (wild-type) and four (CD47 knockout) different genotype-matched animals were pooled and subjected to the analysis on Affymetrix Gene Chip.

INSTRUMENT(S): [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

ORGANISM(S): Mus musculus  

SUBMITTER: Hiroshi Ohnishi 

PROVIDER: GSE118804 | GEO | 2019-03-22

REPOSITORIES: GEO

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Publications


A characteristic subset of microglia expressing CD11c appears in response to brain damage. However, the functional role of CD11c+ microglia, as well as the mechanism of its induction, are poorly understood. Here we report that the genetic ablation of signal regulatory protein α (SIRPα), a membrane protein, induced the emergence of CD11c+ microglia in the brain white matter. Mice lacking CD47, a physiological ligand of SIRPα, and microglia-specific SIRPα-knockout mice exhibited the same phenotype  ...[more]

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