Genomics

Dataset Information

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Expression data of H838 KRAS mutation isogenic cell lines


ABSTRACT: To explore the distinct mechanism of KRAS G12V and G12D mutation. We used microarray to explore the distinct differences in gene expression profiles of H838 KRAS mutation isogenic cell lines Overall design: The RNA of H838 isogenic cell lines were collected in triplicate

INSTRUMENT(S): [Clariom_D_Human] Affymetrix Human Clariom D Assay [transcript (gene) version]

ORGANISM(S): Homo Sapiens

SUBMITTER: Peishan Hung  

PROVIDER: GSE119146 | GEO | 2020-05-21

REPOSITORIES: GEO

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Publications

The Inhibition of Wnt Restrain KRASG12V-Driven Metastasis in Non-Small-Cell Lung Cancer.

Hung Pei-Shan PS   Huang Ming-Hung MH   Kuo Yuan-Yeh YY   Yang James Chih-Hsin JC  

Cancers 20200331 4


The KRAS mutations have been an obstacle to identify therapeutic targets in cancer treatment. In this work, we clarified the distinct metastasis pattern of non-small-cell lung carcinoma (NSCLC) induced by KRASG12V/KRASG12D mutations and inhibited the KRASG12V mediated metastasis by Wnt inhibitor. First, we found that KRASG12V induced more aggressive phenotype in vitro and in vivo experiments. The Gene Set Enrichment Analysis (GSEA) results of H838 KRASG12V cells showed a significant negative cor  ...[more]

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