Dataset Information


Wild-type neutrophils and miR-223 null neutrophils

ABSTRACT: This array analysis is to study the regulation of target messages’ expression in murine neutrophils versus miR-223 null neutrophils. Overall design: Three arrays for wild-type neutrophils and miR-223 null neutrophils

INSTRUMENT(S): [Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array

SUBMITTER: Whitehead Institute  

PROVIDER: GSE12001 | GEO | 2008-07-31



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The impact of microRNAs on protein output.

Baek Daehyun D   Villén Judit J   Shin Chanseok C   Camargo Fernando D FD   Gygi Steven P SP   Bartel David P DP  

Nature 20080730 7209

MicroRNAs are endogenous approximately 23-nucleotide RNAs that can pair to sites in the messenger RNAs of protein-coding genes to downregulate the expression from these messages. MicroRNAs are known to influence the evolution and stability of many mRNAs, but their global impact on protein output had not been examined. Here we use quantitative mass spectrometry to measure the response of thousands of proteins after introducing microRNAs into cultured cells and after deleting mir-223 in mouse neut  ...[more]

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