The AML-associated K313 mutation enhances C/EBPα activity by increasing translation via release of ribosome stalling
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ABSTRACT: Mutations in the transcription factor C/EBPα are found in about 10% of all acute myeloid leukaemia (AML) cases but the contribution of these mutations to leukaemogenesis is incompletely understood. We here use a mouse model of granulocyte progenitors expressing conditionally active HoxB8 to assess the cell biological and molecular activity of C/EBPα-mutations associated with human AML.
ORGANISM(S): Mus musculus
PROVIDER: GSE120473 | GEO | 2020/05/05
REPOSITORIES: GEO
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