The AML-associated K313 mutation enhances C/EBPα activity by increasing translation via release of ribosome stalling

ABSTRACT: Mutations in the transcription factor C/EBPα are found in about 10% of all acute myeloid leukaemia (AML) cases but the contribution of these mutations to leukaemogenesis is incompletely understood. We here use a mouse model of granulocyte progenitors expressing conditionally active HoxB8 to assess the cell biological and molecular activity of C/EBPα-mutations associated with human AML.

ORGANISM(S): Mus musculus

PROVIDER: GSE120473 | GEO | 2020/05/05

REPOSITORIES: GEO