Development of MLL-rearranged leukemia is dependent on a transcriptional program orchestradt by C/EBPα

ABSTRACT: Translocations involving the MLL genes are frequently found in Acute Myeloid Leukemia (AML) and are associated with poor prognosis. The MLL fusion proteins act as aberrant transcription factor activating a transcriptional program that transforms the cells, potentially through collaboration with other transcription factors. To investigate this we searched gene expression profiles from patients with MLL-rearranged AML compared with normal hematopoietic progenitor cells for transcriptional regulators and found targets of C/EBPα to be up-regulated in the AML samples, suggesting that C/EBPα might collaborate with MLL fusion proteins in the initial transformation process. We could show that transformation by MLL fusion proteins is dependent on C/EBPα activity both in early progenitors as well as

ORGANISM(S): Mus musculus

SUBMITTER: Ewa Ohlsson 

PROVIDER: E-GEOD-46534 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress