Expression and ChIP-chip data from REH and SEM leukemia cell lines

ABSTRACT: MLL-fusion proteins are potent inducers of cancer in hematopoietic cells, where they are known to cause changes in global gene expression. How MLL-fusion proteins interact with the genome has not been established, so we have limited understanding of the pathway by which these proteins generate aberrant gene expression programs. Here we describe how the MLL-AF4 protein occupies the genome in human leukemia cells and its striking effects on chromatin states. We find that the MLL-AF4 fusion protein selectively occupies regions of the genome that contain developmental regulatory genes important for hematopoietic stem cell identity and self-renewal. These MLL-AF4 bound regions have grossly altered chromatin structure, with histone modifications catalyzed by Trithorax Group (TrxG) proteins an

ORGANISM(S): Homo sapiens

SUBMITTER: Garrett Frampton 

PROVIDER: E-GEOD-13313 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress