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Analysis of Transcriptional Responses to Altitude-Induced Hypoxia in Bronchial Epithelium, Bronchio-Alveolar Cells, and Blood Reveals Differences Between Smokers and Nonsmokers [alveolar]

ABSTRACT: Blood, bronchial epithelium, and bronchio-alveolar cells were collected in a double blind study. Individuals were exposed to 'ground' and 'flight' conditions using a hypobaric chamber for approximately 5 hours. Blood samples were collected over 4 time points and both bronchial cells were collected at the last time point.

ORGANISM(S): Homo sapiens

PROVIDER: GSE120903 | GEO | 2021/09/14

REPOSITORIES: GEO

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Analysis of Transcriptional Responses to Altitude-Induced Hypoxia in Bronchial Epithelium, Bronchio-Alveolar Cells, and Blood Reveals Differences Between Smokers and Nonsmokers [epithelial]

Project description:Blood, bronchial epithelium, and bronchio-alveolar cells were collected in a double blind study. Individuals were exposed to 'ground' and 'flight' conditions using a hypobaric chamber for approximately 5 hours. Blood samples were collected over 4 time points and both bronchial cells were collected at the last time point.

2021-09-14 | GSE120907 | GEO

Analysis of Transcriptional Responses to Altitude-Induced Hypoxia in Bronchial Epithelium, Bronchio-Alveolar Cells, and Blood Reveals Differences Between Smokers and Nonsmokers [blood]

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Analysis of Transcriptional Responses to Altitude-Induced Hypoxia in Bronchial Epithelium, Bronchio-Alveolar Cells, and Blood Reveals Differences Between Smokers and Nonsmokers [alveolar]

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Analysis of Transcriptional Responses to Altitude-Induced Hypoxia in Bronchial Epithelium, Bronchio-Alveolar Cells, and Blood Reveals Differences Between Smokers and Nonsmokers [blood]

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Analysis of Transcriptional Responses to Altitude-Induced Hypoxia in Bronchial Epithelium, Bronchio-Alveolar Cells, and Blood Reveals Differences Between Smokers and Nonsmokers

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Alterations of human plasma proteome profile on adaptation to high-altitude hypobaric hypoxia

Project description:For individuals migrating to or residing permanently at high-altitude regions, environmental hypobaric hypoxia is a primary challenge which induces several physiological or pathological responses. It is well documented that human beings adapt to hypobaric hypoxia via some protective mechanisms, such as erythropoiesis and overproduction of hemoglobin, however little is known on the changes of plasma proteome profiles in accommodation to high-altitude hypobaric hypoxia. In the present study, we investigated differential plasma proteomes of high altitude natives and lowland normal controls by a TMT-based proteomic approach. A total of 818 proteins were identified, of which 137 were differentially altered. Bioinformatics (including GO, KEGG, protein-protein interactions, etc.) analysis revealed the dysregulated proteins were primarily involved in complement and coagulation cascades, anti-oxidative stress and glycolysis. Validations via magnetic Luminex® Assays and ELISA demonstrated that CCL18, C9, PF4, MPO and S100A9 notably up-regulated, and HRG and F11 down-regulated in high altitude natives compared with lowland controls, which were consistent with the proteomic results. Our findings highlight the roles of complement and coagulation cascades, anti-oxidative stress and glycolysis in acclimatization to hypobaric hypoxia and provide a foundation for developing potential diagnostic or/and therapeutic biomarkers for high altitude hypobaric hypoxia-induced diseases.

2019-03-27 | PXD012221 | Pride

Argentinean high altitude adaptation

Project description:This study evaluates genetic and phenotypic variation in the high altitude Colla population living in the Argentinean Andes above 3500 m. They were compared to the WichÃ population living in the nearby lowlands of the Gran Chaco region. This study attempts to pinpoint evolutionary mechanisms underlying adaptation to hypobaric hypoxia. We have genotyped 25 individuals from both populations for 730,525 SNPs. DNA from 25 saliva samples from Collas living >3500 m and 25 saliva samples from WichÃ living <500 m from the Province of Salta in Argentina was genotyped

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Gene expression from bronchial and nasal epithelial cell samples of healthy current and never smokers.

Project description:mRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy and nasal epithelial cells collected by brushing the inferior turbinate from healthy current and never smoker volunteers in order to determine the relationship between smoking-related gene expression changes in bronchial and nasal epithelium within the same individual.

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