Transcriptomics,Genomics

Dataset Information

36

Human post-mortem brain gene expression from various brain regions from alcoholic and non-alcoholic subjects


ABSTRACT: 4 samples from 9 brain regions Brain tissue from the New South Wales Tissue Resource Centre, 9 brain regions, 4 samples each: 1 male alcoholic, 1 female alcoholic, 1 male control, 1 female control. Brain regions: pre-frontal cortex, cerebral cortex, visual cortex, thalamus, hippocampus, amygdala, caudate nucleus, putamen, cerebellum Overall design: 4 samples from 9 brain regions

INSTRUMENT(S): [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Jeanette Nance McClintick  

PROVIDER: GSE121497 | GEO | 2018-10-18

REPOSITORIES: GEO

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Publications

Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.

McClintick Jeanette N JN   Brooks Andrew I AI   Deng Li L   Liang Li L   Wang Jen C JC   Kapoor Manav M   Xuei Xiaoling X   Foroud Tatiana T   Tischfield Jay A JA   Edenberg Howard J HJ  

Alcohol (Fayetteville, N.Y.) 20140722 6


To elucidate the effects of a controlled exposure to ethanol on gene expression, we studied lymphoblastoid cell lines (LCLs) from 21 alcoholics and 21 controls. We cultured each cell line for 24 h with and without 75 mM ethanol and measured gene expression using microarrays. Differences in expression between LCLs from alcoholics and controls included 13 genes previously identified as associated with alcoholism or related traits, including KCNA3, DICER1, ZNF415, CAT, SLC9A9, and PPARGC1B. The pai  ...[more]

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