Genomics

Dataset Information

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Single-cell chromatin conformation capture of mouse sensory neurons in visual and olfactory systems by Dip-C


ABSTRACT: We performed single-cell chromatin conformation capture with our recently developed method, Dip-C, on mouse sensory neurons in visual and olfactory systems, and reconstructed their 3D genomes. Overall design: We performed Dip-C on 132 cells from the retina and 277 cells from the main olfactory epithelium, extracted chromatin contacts, and generated 3 replicates of 3D genome structures per cell.

INSTRUMENT(S): Illumina HiSeq 2500 (Mus musculus)

ORGANISM(S): Mus musculus  

SUBMITTER: Longzhi Tan  

PROVIDER: GSE121791 | GEO | 2019-02-04

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
GSE121791_00README.md.txt Txt
GSE121791_RAW.tar Raw
GSE121791_genomic_data.b6_d2.chr.txt.gz Txt
GSE121791_genomic_data.cast_b6.chr.txt.gz Txt
GSE121791_genomic_data.enhancers.bed.gz Bed
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Publications

Three-dimensional genome structures of single sensory neurons in mouse visual and olfactory systems.

Tan Longzhi L   Xing Dong D   Daley Nicholas N   Xie X Sunney XS  

Nature structural & molecular biology 20190401 4


Sensory neurons in the mouse eye and nose have unusual chromatin organization. Here we report their three-dimensional (3D) genome structure at 20-kilobase (kb) resolution, achieved by applying our recently developed diploid chromatin conformation capture (Dip-C) method to 409 single cells from the retina and the main olfactory epithelium of adult and newborn mice. The 3D genome of rod photoreceptors exhibited inverted radial distribution of euchromatin and heterochromatin compared with that of o  ...[more]

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