Genomics

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Differential roles of Stella in the modulation of DNA methylation during oocyte and zygotic development


ABSTRACT: In order to obtain genome-wide profiles, base-resolution methylomes of oocytes and zygotes were generated using the bisulfite sequencing (BS-seq) method for small samples. We find that global loss of DNA methylation during zygotic development in HFD mice. A total of 412 DMRs were identified, of which 294 were hypomethylated (hypo-DMRs; 71.4%) and 118 were hypermethylated (hyper-DMRs; 28.6%) (Fig. 6A and 6B), showing a predominance of hypo-DMRs. Furthermore, we show that hyper-DMRs are significantly depleted from CGI, but enriched in short interspersed elements (SINEs) and non-CGI regions. Strikingly, hypo-DMRs are specifically depleted from SINEs, with a concurrent enrichment in DNA transposons. Overall design: Examination of DNA methylome in oocyte and zygote from Stella∆ and WT

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Wenjie Shu  

PROVIDER: GSE122829 | GEO | 2018-11-22

REPOSITORIES: GEO

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