Genomics

Dataset Information

2

Rheumatoid arthritis associated microRNA in peripheral blood mononuclear cells


ABSTRACT: Genome wide microRNA profiling in peripheral blood mononuclear cells from rheumatoid arthritis (RA) patients and healthy controls. The Affymetrix miRNA 4.0 chip was used to obtain RNA profiles in 28 RA patients and 18 healthy controls. Overall design: To identify novel rheumatoid arthritis (RA) associated microRNAs and comprehensively understand their underlying pathologic mechanism, we compared the Affymetrix miRNA 4.0 microarray data from PBMCs of 28 RA patients with that of 18 healthy controls.

INSTRUMENT(S): [miRNA-4] Affymetrix Multispecies miRNA-4 Array [ProbeSet ID version]

ORGANISM(S): Homo sapiens  

SUBMITTER: Xingbo Mo  

PROVIDER: GSE124373 | GEO | 2020-03-17

REPOSITORIES: GEO

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Publications

Epigenetically regulated co-expression network of genes significant for rheumatoid arthritis.

He Pei P   Mo Xing-Bo XB   Lei Shu-Feng SF   Deng Fei-Yan FY  

Epigenomics 20191106 14


<b>Aim:</b> To identify epigenetically regulated network of genes in peripheral blood mononuclear cells significant for rheumatoid arthritis (RA). <b>Methods:</b> Differentially expressed genes (DEGs) and their associated differentially expressed miRNAs and differentially methylated positions (DMPs) were identified. Causal inference test (CIT) identified the causal regulation chains. The analyses, for example, weighted gene co-expression network (WGCNA), protein-protein interaction and functiona  ...[more]

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