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Gene expression-based global role of CovR in GBS A909 using stk1 deletion mutant

ABSTRACT: Global regulatory roles of the TCS response regulator CovR in GBS serotype 1a A909 Keywords: Strain comparison; global regulation

ORGANISM(S): Streptococcus agalactiae A909 Streptococcus agalactiae

PROVIDER: GSE12463 | GEO | 2010/08/14

SECONDARY ACCESSION(S): PRJNA113031

REPOSITORIES: GEO

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Gene expression-based global role of CovR in GBS A909

Project description:Global regulatory roles of the TCS response regulator CovR in GBS serotype 1a A909 Keywords: Strain comparison; global regulation

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Gene expression-based global role of CovR in GBS A909 using stk1 deletion mutant

Project description:Global regulatory roles of the TCS response regulator CovR in GBS serotype 1a A909 Keywords: Strain comparison; global regulation Deletion mutant was examined for alterations in gene expression

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Gene expression-based global role of CovR in GBS A909

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Project description:We report the characterization of the major regulator of virulence gene expression (CovR) in Group B Streptococcus. The ChIP-seq experiments define the binding of CovR on the chromosome of the BM110 strain, a representative of the hypervirulent GBS lineage responsible of neonatal meningitis. Regulatory evolution of CovR signaling was investigated by comparing ChIP-seq done in parallel in a second GBS clinical isolate (NEM316) not belonging to the hypervirulent lineage.

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Effect of CovR polymorphisms on GAS gene expression

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2011-11-01 | E-GEOD-32106 | biostudies-arrayexpress

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Project description:JRS4 is our wild-type M6 serotype strain and JRS948 is the isogenic covR strain. Keywords: 2-channel

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Transcriptomic analysis of the major regulator of virulence CovR in Group B Streptococcus strains BM110 and NEM16.

Project description:To define the transcriptional response associated to a CovR inactivation we performed RNA-Seq in GBS strains BM110 and NEM316. We used mutants in which CovR is inactivated following a two base-pairs chromosomal substitution (AT->CC) resulting in the translation of a CovRD53A variant unable to be phosphorylated by the histidine kinase CovS. We also used a ∆covR mutant in strain BM110 in which the covR sequence is deleted from the chromosome.

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Project description:Gene expression-based global role of CovR in GBS A909

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A vaginal tract signal detected by the GBS SaeRS system elicits transcriptomic changes and enhances murine colonization.

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