Genomics,Multiomics

Dataset Information

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Glucocorticoids Promote Breast Cancer Metastasis


ABSTRACT: Next Generation Sequencing was applied to investigate the heterogeneity between tumors and distant metastases in different models of Breast Cancer cell lines and primary-derived xenografts. Global transcriptional profiling of the primary tumor and matched distant metastases (lung, liver, spleen) as well as circulating tumor cells (CTCs) allowed to identify glucocorticoid signalling as a mediator of metastasis. Overall design: RNA-Seq in 4 different Breast Cancer models to investigate glucorticoid signalling role in metastasis

OTHER RELATED OMICS DATASETS IN: PXD009102

INSTRUMENT(S): Illumina HiSeq 2500 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Mohamed Bentires-Alj  

PROVIDER: GSE124817 | GEO | 2019-03-14

REPOSITORIES: GEO

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Publications


Diversity within or between tumours and metastases (known as intra-patient tumour heterogeneity) that develops during disease progression is a serious hurdle for therapy<sup>1-3</sup>. Metastasis is the fatal hallmark of cancer and the mechanisms of colonization, the most complex step in the metastatic cascade<sup>4</sup>, remain poorly defined. A clearer understanding of the cellular and molecular processes that underlie both intra-patient tumour heterogeneity and metastasis is crucial for the  ...[more]

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