RNA sequencing of lung innate lymphoid cell (ILC) populations

ABSTRACT: A transitory, interleukin-25-responsive, KLRG1high Group 2 innate lymphoid (ILC2) cell subset that migrates to mucosal tissues early during type-2 inflammation was recently identified. This study focuses on understanding the significance of this population in relation to tissue-resident ILC2 cells in the lung and intestine.  RNA-sequencing and unbiased pathway analysis revealed the AP-1 factor BATF as a potential modulator of ILC2 cell fate. For RNAseq, KLRG1-postive and KLRG1-neagive populations were sorted and compared.

ORGANISM(S): Mus musculus

PROVIDER: GSE125816 | GEO | 2020/03/02

REPOSITORIES: GEO