Genomics,Multiomics

Dataset Information

0

Genomic instability in the naturally and prematurely aged myocardium [variants: data set 2]


ABSTRACT: Our data demonstrate that genomic instability does not evidently contribute to naturally aging of the mouse heart and support the contention that the endogenous DNA repair machinery is remarkably active to maintain genomic integrity in cardiac cells throughout life. Overall design: Investigation of variants in samples from small intestine, liver and spleen tissues of naturally aged mice of 12 and 104 weeks of age.

INSTRUMENT(S): Illumina NextSeq 500 (Mus musculus)

ORGANISM(S): Mus Musculus

SUBMITTER: Monika Stoll 

PROVIDER: GSE129278 | GEO | 2021-09-15

REPOSITORIES: GEO

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Publications


Genomic instability, the unresolved accumulation of DNA variants, is hypothesized as one of the contributors to the natural aging process. We assessed the frequency of unresolved DNA damage reaching the transcriptome of the murine myocardium during the course of natural aging and in hearts from four distinct mouse models of premature aging with established aging-related cardiac dysfunctions. RNA sequencing and variant calling based on total RNA sequencing was compared between hearts from natural  ...[more]

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