Transcriptomics,Genomics

Dataset Information

18

Gene profiling of young rats susceptible to malaria infection


ABSTRACT: The study was performed in order to determine molecular markers potentially involved in the susceptibility of young rats to the infection with Plasmodium berghei Anka Overall design: In this study, we compared the microarrays of spleens (using the rat Codelink developed by Amersham Biosources) obtained from young rats infected by Plasmodium berghei Anka with those of uninfected age matched controls.

INSTRUMENT(S): Amersham Biosciences Codelink uniset rat 1 Bioarray

SUBMITTER: Jamal Khalife   

PROVIDER: GSE13014 | GEO | 2009-10-01

SECONDARY ACCESSION(S): PRJNA112553

REPOSITORIES: GEO

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Publications

Gene profiling analysis reveals the contribution of CD24 and P2Y6R to the susceptibility of young rats to Plasmodium berghei infection.

Pierrot Christine C   dit Vampouille Aurore Acroute AA   Vandomme Audrey A   Lafitte Sophia S   Pierce Raymond J RJ   Hot David D   Khalife Jamal J  

Cellular microbiology 20110216 5


Our previous studies have shown that Plasmodium berghei infection induces distinct clinical, parasitological and immunological states in young susceptible rats versus adult resistant rats. This susceptibility was mainly found to be related to inadequate cellular responses. In this study we first identified the altered genes in young susceptible rats. Unexpectedly, transcriptome analysis did not reveal any alteration of effector cytokines or their receptors. At day 13 p.i., six transcripts corres  ...[more]

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