Transcriptomics,Genomics

Dataset Information

11

Transcriptomes of microglia in experimental cerebral malaria in mice in the presence and absence of Type I Interferon signaling


ABSTRACT: Plasmodium berghei ANKA infection in mice is used as a model for human cerebral malaria, the most severe complication of Plasmodium falciparum infection. The response of brain cells such as microglia has been little investigated, and may play a role in the pathogenesis or regulation of cerebral malaria. We showed previously that microglia are activated in P. berghei infections, and that Type 1 Interferon signaling is important for activation. This dataset contains the transcriptome of brain microglia of infected mice in the presence and absence of Type I interferon signaling, with the aim of identifying the genes involved in this pathway in microglia during experimental cerebral malaria. Refererence: Capuccini et al 2016, Scientific Reports, 6:39258 The global gene expression profiles from RNA of microglia isolated from uninfected and P berghei-infected wild-type C57BL/6 mice and and IFNA Receptor Knock-out mice using Illumina Beadarrays. Overall design: Total RNA from Female C57BL/6 wildtype and IFNA Receptor knock-out mice injected with 105 Plasmodium berghei ANKA infected red blood cells intraperitoneally compared to untreated mice of the same genotype.

INSTRUMENT(S): Illumina MouseWG-6 v2.0 expression beadchip

SUBMITTER: Richard James Mitter 

PROVIDER: GSE119650 | GEO | 2018-09-07

REPOSITORIES: GEO

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Publications

Transcriptomic profiling of microglia reveals signatures of cell activation and immune response, during experimental cerebral malaria.

Capuccini Barbara B   Lin Jingwen J   Talavera-López Carlos C   Khan Shahid M SM   Sodenkamp Jan J   Spaccapelo Roberta R   Langhorne Jean J  

Scientific reports 20161219


Cerebral malaria is a pathology involving inflammation in the brain. There are many immune cell types activated during this process, but there is little information on the response of microglia, in this severe complication. We examined microglia by genome wide transcriptomic analysis in a model of experimental cerebral malaria (ECM), in which C57BL/6 mice are infected with Plasmodium berghei ANKA. Thousands of transcripts were differentially expressed in microglia at two different time points du  ...[more]

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