Genomics

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SMAD3 ChIP-seq in Triple-Negative Breast Cancer Cells


ABSTRACT: Triple-negative breast cancer (TNBC) is highly dependent on oncogenic transforming growth factor β (TGFβ) signaling for its survival and aggressive/invasive growth characteristics. SMAD3, the transcription factor that transduces the TGFβ signal within these tumor cells, is critical for establishing and maintaining the aggressive phenotypes associated with TNBC. To provide a better understanding of SMAD3 function in this context, we identified binding sites in two TNBC cell lines, WHIM12 and SUM159. Overall design: SMAD3 ChIP-seq was performed in two TNBC cell lines in duplicate, without TGFβ stimulation.

INSTRUMENT(S): Illumina NextSeq 500 (Homo sapiens)

ORGANISM(S): Homo sapiens  

SUBMITTER: Angelique Whitehurst  

PROVIDER: GSE130364 | GEO | 2019-06-19

REPOSITORIES: GEO

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