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Genomic binding profiles for ZNF165, ZNF446, and SMAD3 in triple-negative breast cancer

ABSTRACT: Genomic binding profiles for ZNF165, ZNF446, and SMAD3 in triple-negative breast cancer

PROVIDER: PRJNA539904 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11513100.fastq.gz	Fastqsanger.gz
	SRR11513101.fastq.gz	Fastqsanger.gz
	SRR11513102.fastq.gz	Fastqsanger.gz
	SRR11513103.fastq.gz	Fastqsanger.gz
	SRR11513104.fastq.gz	Fastqsanger.gz

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Genomic binding profiles for ZNF165, ZNF446, and SMAD3 in triple-negative breast cancer

Project description:The testis protein ZNF165 is aberrantly expressed in triple-negative breast cancer (TNBC), where it modulates TGFβ signaling to promote tumor growth and survival. To investigate whether ZNF165 functions in this capacity via cooperation with SMAD3, a canonical TGFβ-induced transcription factor, we performed ChIP-seq for both factors in TNBC cell lines (WHIM12 and SUM159). Additionally, we established genomic binding profiles for ZNF446, a previously uncharacterized transcription factor that we have identified as a member of a ZNF165-SMAD3 complex.

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