USP8 mutations determine genes’ expression profile of pituitary corticotroph adenomas, regardless of tumor functional status.

ABSTRACT: The aim of the study was to compare genes’ expression profiles of functioning and silent corticotroph adenomas to investigate possible biological mechanism of different hormone secretion . Since USP8 is the best know driver gene mutated in large proportion of ACTH-omas we intended to verify whether the mutation occurs in SCAs and how it affects transcriptomic profile.

ORGANISM(S): Homo sapiens

PROVIDER: GSE132982 | GEO | 2019/06/20

REPOSITORIES: GEO