Ontology highlight
ABSTRACT:
OTHER RELATED OMICS DATASETS IN: PXD015173
INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)
ORGANISM(S): Mus musculus
SUBMITTER: Chen Chu
PROVIDER: GSE134645 | GEO | 2020-04-04
REPOSITORIES: GEO
Action | DRS | |||
---|---|---|---|---|
GSE134645_Dot1l_KO_LIF.csv.gz | Csv | |||
GSE134645_Dot1l_KO_Wnt.csv.gz | Csv | |||
GSE134645_H3K79me2_3MB_Peaks.bed.gz | Bed | |||
GSE134645_H3K79me2_DMSO_Peaks.bed.gz | Bed | |||
GSE134645_ThioChIP_Peaks.bed.gz | Bed |
Items per page: 5 1 - 5 of 6 |
Michowski Wojciech W Chick Joel M JM Chu Chen C Kolodziejczyk Aleksandra A Wang Yichen Y Suski Jan M JM Abraham Brian B Anders Lars L Day Daniel D Dunkl Lukas M LM Li Cheong Man Mitchell M Zhang Tian T Laphanuwat Phatthamon P Bacon Nickolas A NA Liu Lijun L Fassl Anne A Sharma Samanta S Otto Tobias T Jecrois Emanuelle E Han Richard R Sweeney Katharine E KE Marro Samuele S Wernig Marius M Geng Yan Y Moses Alan A Li Cheng C Gygi Steven P SP Young Richard A RA Sicinski Piotr P
Molecular cell 20200401 3
The cyclin-dependent kinase 1 (Cdk1) drives cell division. To uncover additional functions of Cdk1, we generated knockin mice expressing an analog-sensitive version of Cdk1 in place of wild-type Cdk1. In our study, we focused on embryonic stem cells (ESCs), because this cell type displays particularly high Cdk1 activity. We found that in ESCs, a large fraction of Cdk1 substrates is localized on chromatin. Cdk1 phosphorylates many proteins involved in epigenetic regulation, including writers and ...[more]